Hyruan One Special Precautions

General precautions: Administration of Hyruan ONE to severely inflamed joints caused by deformative osteoarthritis can lead to exacerbation of the local inflammation symptom. Thus, Hyruan ONE is desired to be given after the removal of existing inflammation symptoms.
Administration of Hyruan ONE may occasionally cause local pain or swelling, therefore patients should be informed to avoid strenuous exercise or action leading joint pain of knee up to 48 hours after administration, and actions such as local relaxation should be guided after injection.
Leakage of Hyruan ONE other than articular cavity might cause pain; therefore Hyruan ONE should be accurately injected into articular cavity.
Precautions in use: Since Hyruan ONE is injected directly into the joints, administration should be performed under intact sterilization status.
In case of retention of articular fluid, the fluid should be removed by puncturing prior to administration of Hyruan ONE, if necessary.
Intravascular injection, extra-articular injection or injection in the synovial tissues should be avoided.
It is desirable to administer the product using enclosed needles.
Care should be taken with a disinfectant fourth-grade ammonium salt such as benzalkonium chloride and chlorhexidine.
Hyruan ONE is intended for single use only. No re-sterilization or reuse is allowed. Do not use if packaging or syringe is opened or damaged.
The injection site must be sterilized either by alcohol or other disinfecting solution prior to administration.
Used syringe, needle and unused materials all need to be discarded after administration.
In case Hyruan One is injected into both sides of knee, a separate product should be applied for each administration.
Precautions in Handling: Hyruan ONE should be kept away from children.
Hyruan ONE should be kept in original packaging; storing Hyruan ONE in a different packaging can cause misuse of product or decline the product quality.
Effects on ability to drive and use machine: Not known.